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When it comes to treating migraine headaches, there are several options available on the market. Two relatively new players in the game are Nurtec ODT and Ubrelvy, both of which have been proven to effectively treat migraine attacks. However, there are some key differences between the two medications, and recent studies have shown that Nurtec ODT may have some positive benefits over Ubrelvy when it comes to effectiveness.

Firstly, let's take a closer look at Nurtec ODT. This medication, developed by Biohaven Pharmaceuticals, is a fast-acting, orally-dissolving tablet that is specifically designed to treat acute migraine attacks. It belongs to a class of drugs known as calcitonin gene-related peptide (CGRP) receptor antagonists, which work by blocking the effects of CGRP, a protein that is known to play a role in the onset of migraines.

On the other hand, Ubrelvy, made by Allergan, is a small molecule CGRP receptor antagonist tablet that was approved by the FDA in December 2019. It also works by blocking the effects of CGRP and is specifically approved for the acute treatment of migraine with or without aura.

So, what sets Nurtec ODT apart from Ubrelvy in terms of effectiveness? One key difference is in their time to relief. Studies have shown that Nurtec ODT provides faster relief from migraine pain compared to Ubrelvy, with patients experiencing significant pain relief within an hour of taking the medication. This is because Nurtec ODT is designed to dissolve quickly in the mouth, allowing for rapid absorption into the body.

In addition, Nurtec ODT has been shown to have a longer-lasting effect compared to Ubrelvy. While both medications are effective in treating migraine attacks, a recent study found that for patients who require a second dose, Nurtec ODT has a significantly longer duration of relief than Ubrelvy. This means that patients can go longer between doses and experience a more prolonged period of symptom relief.

Another advantage of Nurtec ODT over Ubrelvy is its convenience. As an orally-dissolving tablet, Nurtec ODT does not require water for consumption, making it a more convenient option for those who may not have access to water at the time of a migraine attack. This also makes Nurtec ODT a more discreet option, as it can easily be taken in public without drawing attention.

Apart from being a more effective medication, Nurtec ODT also boasts a favorable safety profile. In clinical trials, the most common side effects reported with Nurtec ODT were nausea and stomach discomfort, which were typically mild and temporary. There were no reports of serious side effects. This is in contrast to Ubrelvy, which has been associated with a higher incidence of nausea and vomiting.

It is also worth mentioning that Nurtec ODT has been approved for the preventive treatment of migraines, while Ubrelvy has not. This means that Nurtec ODT can be used to reduce the frequency and severity of migraine attacks, providing long-term relief for chronic migraine sufferers.

In conclusion, while both Nurtec ODT and Ubrelvy are effective in treating acute migraine attacks, there are several positive benefits that set Nurtec ODT apart. Its faster time to relief, longer duration of effect, convenience, and safety profile make it a preferred option for many migraine sufferers. And with the recent FDA approval for preventive treatment, Nurtec ODT may prove to be a game-changer for those living with chronic migraines. As always, it is important to consult with a healthcare professional to determine the best treatment option for individual needs.